Cocaine Activates Genes Through Chromatin Remodeling
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چکیده
Chromatin remodeling contributes to healthy adaptations, including learning and memory, and to diseases, including schizophrenia. Dr. Eric Nestler and colleagues at the University of Texas Southwestern Medical Center and Harvard Medical School revealed its role in cocaine pathology. In a series of experiments with rats, they demonstrated that cocaine-induced chromatin remodeling increases the production rates of four proteins that have been implicated in cocaine addiction: cFos, ∆ FosB, BDNF, and Cdk5.
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2007